Effect of combining estradiol valerate with sildenafil in increasing the thickness of the endometrium in infertile women before intrauterine insemination: a randomized clinical trial

Background: Therapies available for thin endometrium are limited and mostly performed experimentally which most of these treatments have a similar function increase blood flow to the endometrium, causing it thicken develop. The aim study was compare effect estradiol valerate in combination with sildenafil on endometrial thickness infertile women before intrauterine insemination. Methods: In this randomized clinical trial 100 referred Reyhaneh Infertility Center Ardabil were randomly divided into two groups. Patients' assessed by vaginal ultrasound treatment then day 9 cycle. intervention group received one tablet every 12 h from ninth menstruation 4 days as 25 mg orally daily 12, but control group, patients placebo tablets addition estradiol. Results: There no statistically significant difference between groups after term thickness. rate 1.35 mm 1.37 not significant. Conclusions: Estradiol alone or resulted increasing oral supplementation had